Activision a annoncé que la version Wii de Guitar Hero World Tour accueillera du contenu téléchargeable dès sa sortie. Seront donc disponibles les morceaux suivants :
* An Endless Sporadic – “Anything” (gratuit)
 * Blind Melon – “No Rain” (200 Wii Points)
 * Boston – “Rock and Roll Band” (200 Wii Points)
 * Foreigner – “Hot Blooded” (200 Wii Points)
 * Metallica – “Broken, Beat & Scarred” (200 Wii Points)
 * Metallica – “Cyanide” (200 Wii Points)
 * Metallica – “My Apocalypse” (200 Wii Points)
 * Rick Springfield – “Jessie’s Girl” (200 Wii Points)
 * Sworn – “Electro Rock” (free)
 * Ted Nugent’s Original Guitar Duel (free)
 * Zakk Wylde’s Original Guitar Duel (free)
Dans les semaines suivants le lancement, ces chansons seront disponibles :
* Oasis – “Bag it Up” (200 Wii Points)
 * Oasis – “The Shock of the Lightning” (200 Wii Points)
 * Oasis – “Waiting for the Rapture” (200 Wii Points)
 * R.E.M. – “Horse to Water” (200 Wii Points)
 * R.E.M. – “Man-Sized Wreath” (200 Wii Points)
 * R.E.M. – “Supernatural Superserious” (200 Wii Points)